Sildenafil in Use for Treatment of Pulmonary Hypertension in Congenital Diaphragmatic Hernia: Short Literature Review
نویسنده
چکیده
Congenital Diaphragmatic Hernia (CDH) is a complex malformation in the newborn baby. The management, either surgical or non-surgical is an ongoing challenge. Especially in regard to the question how to treat the concomitant pulmonary hypertension best. Here sildenafil, more commonly known in the public as Viagra® and for the treatment of erectile dysfunction seems to have beneficial effects in pulmonary hypertension treatment of CDH patients as well. Thus, this short review aims to evaluate the actual literature for current evidence and practical application.
منابع مشابه
Standardized Postnatal Management of Infants with Congenital Diaphragmatic Hernia in Europe: The CDH EURO Consortium Consensus - 2015 Update.
In 2010, the congenital diaphragmatic hernia (CDH) EURO Consortium published a standardized neonatal treatment protocol. Five years later, the number of participating centers has been raised from 13 to 22. In this article the relevant literature is updated, and consensus has been reached between the members of the CDH EURO Consortium. Key updated recommendations are: (1) planned delivery after ...
متن کاملVascular Medicine Antenatal Sildenafil Treatment Attenuates Pulmonary Hypertension in Experimental Congenital Diaphragmatic Hernia
Background—Lung hypoplasia and persistent pulmonary hypertension of the newborn limit survival in congenital diaphragmatic hernia (CDH). Unlike other diseases resulting in persistent pulmonary hypertension of the newborn, infants with CDH are refractory to inhaled nitric oxide (NO). Nitric oxide mediates pulmonary vasodilatation at birth in part via cyclic GMP production. Phosphodiesterase type...
متن کاملAntenatal sildenafil treatment attenuates pulmonary hypertension in experimental congenital diaphragmatic hernia.
BACKGROUND Lung hypoplasia and persistent pulmonary hypertension of the newborn limit survival in congenital diaphragmatic hernia (CDH). Unlike other diseases resulting in persistent pulmonary hypertension of the newborn, infants with CDH are refractory to inhaled nitric oxide (NO). Nitric oxide mediates pulmonary vasodilatation at birth in part via cyclic GMP production. Phosphodiesterase type...
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BACKGROUND Lung hypoplasia, pulmonary persistent hypertension of the newborn and its morphological changes are the main features in congenital diaphragmatic hernia (CDH). This study was undertaken to investigate if antenatal use of sildenafil and/or bosentan attenuates vascular remodeling, promotes branching, and improves alveolarization in experimental nitrofeninduced CDH. METHODS Nitrofen (...
متن کاملUpdate on PPHN: mechanisms and treatment.
Persistent pulmonary hypertension of the newborn (PPHN) is a syndrome of failed circulatory adaptation at birth, seen in about 2/1000 live born infants. While it is mostly seen in term and near-term infants, it can be recognized in some premature infants with respiratory distress or bronchopulmonary dysplasia. Most commonly, PPHN is secondary to delayed or impaired relaxation of the pulmonary v...
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تاریخ انتشار 2014